Previous studies have found that DDX5 can regulate the expression of AKT and phosphorylation in colorectal cancer, thus affecting the development of colorectal cancer.7 It has also been reported that DDX5 can regulate the phosphorylation activity of mTOR and S6K1 in gastric cancer, thereby affecting the progression of gastric cancer.4 We found that knockdown of OGT significantly inhibited AKT/mTOR signalling pathway activity (Figure 4A). This evidence concerns the gene DDX5 and colorectal cancer.