Recent studies have shown that O‐GlcNAcylation can modify multiple groups of oncogenic factors, and that up‐regulation of O‐GlcNAcylation is involved in tumour malignancies.22, 28, 29, 30 For example, modifications of p53 and c‐Myc and O‐GlcNAcylation will increase their stability by blocking ubiquitin degradation.16, 20 In addition to stabilizing carcinogenic factors, O‐GlcNAcylation also regulates its transcriptional activity. This evidence concerns the gene TP53 and neoplasm.