A recent study showed that DDX5 is significantly higher in colorectal cancer than normal tissues, and DDX5 is involved in phosphorylation of AKT and mTOR.7 It has also been reported that activated mTOR signalling leads to increased expression of OGT and O‐GlcNAcylation in colorectal cancer.14 Moreover, increased levels of O‐GlcNAcylation activate the mTOR signal, suggesting that there may be a feedback regulatory loop between the mTOR signalling pathway and O‐GlcNAcylation. This evidence concerns the gene AKT1 and colorectal cancer.