In contrast, decreased NF‐κB activity was observed in Rap1‐/‐BMSCs, which displayed more resistance to apoptosis and presented better cardioprotective effects in myocardial infarction mice than wild‐type BMSCs.90 Similarly, the results from mice fed a high fat diet (HFD) identified HFD‐induced activation of NF‐κB in MSCs, contributing to the reduced expression of VEGFA and bFGF.91 In conclusion, the exact role NF‐κB plays in MSCs is still debated. The gene discussed is NFKB1; the disease is myocardial infarction.