IGF1 and acute kidney injury: Lastly, many studies have confirmed preconditioning with insulin‐like growth factor‐1 (IGF‐1) may enhance MSC proliferation with lower apoptosis in many other organ failure models.33, 34 In AKI, Xinaris et  al found that the number of IGF‐1‐treated MSCs was increased in the injured kidney at day 1 and remained higher at day 4, partly due to the mechanism that preconditioned cells were more resistant to the oxidative damage induced by H2O2 in vitro.35