Berezina et al.7 studied 503patients with abdominal obesity and concluded that the MHO phenotype was associatedwith younger age, smaller WC, higher physical activity level, shorter duration ofobesity, and presence of the G45G adiponectin genotype.7 However, the greatest challenge is establishing acutoff point for WC that can be applied to different obese populations. This evidence concerns the gene ADIPOQ and Abdominal obesity.