Although our findings provide a new insight into post-lipectomy catabolism of cholesterol in experimental model, further studies are needed to determine an association between hypercholesterolemia, circulating PCSK9 concentrations and up-regulation of genes encoding PCSK9, HNF1α, and HNF4α in humans subjected to liposuction or patients with lipodystrophy. Here, HNF4A is linked to familial hypercholesterolemia.