CXCL12 and colorectal cancer: A recent study by Zhang et al. also reported that CD133+ human umbilical HPCs might induce the proliferation or metastasis of colorectal cancer cells in the liver and impact the expression of their derived proteins such as mitogen-activated protein kinase 4 (MAPK4), stromal cell-derived factor-1 (SDF-1), MMP-9, calumenin, peripherin, leucine zipper, putative tumor suppressor 1, and guanidinoacetate methyltransferase (Lei et al. 2018).