PDGFRB and neoplasm: They further clarified that tumor-specific factors can upregulate the expression of very late antigen-4 (VLA-4) ligand and fibronectin at distant pre-metastatic sites, recruit platelet-derived growth factor receptor (PDGFR)-expressing cells, and make the pre-metastatic niches ready for incoming tumor cells (Sahoo et al. 2018).