It is well known that the PI3K/AKT and MEK/ERK pathways play important roles in regulating cancer cell invasion or migration (Chang et al. 2018; Bollaert et al. 2018; Zhang et al. 2018b; Shults et al. 2018; Yan et al. 2018; Johnsen et al. 2018). This evidence concerns the gene AKT1 and cancer.