The second aim was to find changes in the values of liver enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT), and the association between liver enzymes and glycated haemoglobin in chronic alcohol abusers in addition to liver damage diagnosed on the basis of macroscopic findings and to find out cases of possible secondary diabetes. This evidence concerns the gene GPT and alcohol dependence.