SCN10A and cardiac rhythm disease: NaV1.8 was reported to modulate SCN5A expression and cardiac electrophysiology in heart [59], and genome-wide association study (GWAS) showed that single nucleotide polymorphisms in SCN10A were associated with cardiac conduction defects, including rs6795970, rs6798015, rs6800541 and rs7430477 [60], suggesting that SCN10A plays an important role in cardiac arrhythmia.