Collectively, these new LSPs contain 8 promiscuous CD4+ T-cell epitopes (30, 34) overlapping with 6 main described CD8+ T-cell epitopes restricted to HLA-A2, A3, A1, and A24 for which spontaneous CD8+ T-cell responses have been identified in numerous cancer patients (26–29, 35, 36) (Table 1). This evidence concerns the gene CD4 and cancer.