Determination of useful biomarkers for the detection of malignancy in thyroid nodules is currently in progress and various molecular markers have been proposed including mutation-based markers like B-RAF, NRAS, PAX8/PPARγ, and RET/PTC translocations (3), and immunocytochemistry based markers like galectin3, fibronectin, thyroglobulin, CD44V6, cytokeratin 19, HBME-1, VEGF, and Aurora-A (7), but the introduced markers for thyroid cancer do not have good specificity and positive predictive value (8). This evidence concerns the gene RET and thyroid cancer.