Inactivity increases the risk of death from heart problems.   16  Exercise decreases sympathetic activity and blood pressure by increasing glucose metabolism and insulin sensitivity.   6  Regardless of the beneficial effects of physical activity on hypertension, hypoglycemia, and dyslipidemia in patients with type 2 diabetes, physical activity is the only intervention that directly leads to an increase in cardiorespiratory fitness.   8  Aerobic exercise increases skeletal muscle capillary density and maximum oxygen consumption.   17. Here, INS is linked to type 2 diabetes mellitus.