FMR1 and fragile X-associated tremor/ataxia syndrome: Another novel finding from the present study is that the genotype-phenotype relationships extend beyond the middle cerebellar peduncles and the adjacent white matter – the region that has been considered a major target for FMR1 mRNA toxicity and highly relevant to the clinical manifestations of FXTAS (Hagerman and Hagerman, 2013, 2016).