Considering the results of these comparisons, it was of interest to test the assumption that the fall in AMPK activity levels between Non-FXTAS and FXTAS groups corresponded to the appearance or increase in severity of tremor/ataxia – the most typical neurological changes in FXTAS – as measured by the ICARS scores. The gene discussed is PRKAA1; the disease is fragile X-associated tremor/ataxia syndrome.