Interestingly, this study also demonstrates that treatment of tumor-bearing mice with epigenetic modulators, i.e., combination of EZH2 and DNMT1 inhibitors, increases tumor expression of CXCL9/CXCL10 and improves therapeutic efficacy of anti-PDL1 antibody and adoptive transfer of CD8+ T cells by enhancing T cell migration toward tumors. This evidence concerns the gene CD8A and neoplasm.