A phase I trial of a small molecule inhibitor of CCR2 (CCX872) in combination with chemotherapy (FOLFIRINOX regimen) has also been performed in patients with non-resectable pancreatic cancer (ClinicalTrials.gov ID: NCT02345408) in which overall survival (OS) at 18 months was 29% for CCX872/FOLFIRINOX combination therapy, whereas it was 18.6% for FOLFIRINOX alone (102). This evidence concerns the gene CCR2 and familial pancreatic carcinoma.