Adoptively transferred human classical monocytes (CD14+CD16−CCR2+) also migrate to the metastatic tumors established by 4173 human breast cancer cells (a highly metastatic derivative from MDA-MB-231 cells) in nude mice, and this monocyte recruitment is inhibited by treatment with neutralizing antibodies against either mouse (host stromal cell-derived) or human (cancer cell-derived) CCL2 (43). This evidence concerns the gene CCL2 and cancer.