Interestingly, a recent study using a mouse model of breast cancer showed that TAMs are recruited via CCR2 signaling to primary tumors where they induce CXCR4 expression in response to tumor-derived TGFβ and then migrate toward the blood vessel via CXCL12 to promote intravasation of cancer cells (83). This evidence concerns the gene CXCR4 and neoplasm.