A recent study showed that treatment with an antagonist for insulin like growth factor 1 (IGF-1) receptor reduces expression of CCL2 and suppresses MAM accumulation in MC38 metastatic tumors in the liver (89), suggesting IGF-1 as a key regulator of chemokine induction in the microenvironment of tumor-challenged liver. The gene discussed is IGF1; the disease is metastatic neoplasm.