In subcutaneous tumors established by LLC lung cancer cells, chemotherapy (cyclophosphamide) treatment increases CXCL12 expression around blood vessels and recruits TAMs to the perivascular area through CXCR4 (81), whereas CCL2 from cancer cells promotes TAM accumulation in the LLC tumors without receiving any chemotherapy (82). This evidence concerns the gene CXCR4 and lung carcinoma.