A recent study using mouse models of ovarian cancer has shown that the reduced production of CXCL9 and CXCL10 from cancer cells is caused by enhancer of zeste homolog 2 (EZH2) mediated histone modification and DNA methyltransferase 1 (DNMT1) mediated DNA methylation of the chemokine genes (129). The gene discussed is CXCL10; the disease is ovarian carcinoma.