They aimed either to limit the initial SIRS (and thus the CARS) in particular by the use of low dose glucocorticoids (20, 91, 110) or to restore or supplement the secretion of pro-inflammatory cytokines by the injection of IFN-γ, GM-CSF (110) or interleukin-12 (10). The gene discussed is IFNG; the disease is systemic inflammatory response syndrome.