•Pro-tumourigenic TAN (N2) in late tumourigensis•Expression of cytokines (TGFβ, CXCL8) growth factors (VEGF), (arginase, ROS), ECM remodeling (MMP-9)•Promotes angiogenesis, metastasis, cancer cell proliferation•Induce NK anergy. The gene discussed is CXCL8; the disease is cancer.