TNF and cancer: •Anti-tumourigenic (N1) during early tumourigenesis•Secrete cytokines (IFNγ, TNFα)•TRAIL and FasL-mediated apoptosis of cancer cells•apoptosis of cancer cells•Antibody-dependent cell-mediated cytotoxicity (ADCC) of cancer cells•Elimination of tumor cells during early tumourigenesis activate T Cells