•Exhaustion of T-cell activities•Induce NK anergy•Inhibit T-cell infiltration•Induces TAM differentiation•Strongly promotes immunosuppressive tumor environment•Induces EMT•Enhance tumor cell migration and preparing the pre-metastatic niche•Secrete (M-CSF), growth factors (VEGF), immunosuppressive molecules (ROS, iNOS, ARG1). This evidence concerns the gene VEGFA and neoplasm.