CD4 and neoplasm: •Assists in priming of CD4+ and CD8+ T cells through tumor antigens•Adaptive immune response•Secretes cytokines (IL-2, IL-12, type I IFN), T-cells costimulatory molecules and cytokines for Th1 and Th17 priming (TREM-1)•Links the innate and adaptive immunity as antigen-presenting cells