NLRP3 and type 2 diabetes nephropathy: We previously reported that mitochondrial ROS is crucial for the activation of the NLRP3 inflammasome in macrophages by hyperuricemia in type 2 diabetic nephropathy and the mitochondrially targeted antioxidant, Mito-TEMPO, attenuated NLRP3 increase, and IL-1β release (9).