Our results showed that the intracellular Na+ concentration in TGEV-infected cells increased before 48 h p.i. One of the likely explanations was that in IPEC-J2 cells with TGEV infection, SGLT1 could transport extracellular Na+ into the cells down a concentration gradient during the early phase of infection with TGEV, to increase intracellular glucose intake. Here, SLC5A1 is linked to infection.