IFI35 and viral infectious disease: Interestingly, IFP35 have been found to negatively impact the activation of RIG-I favoring virus infection (Das et al., 2014), however, overexpression of FMDV 2C in HEK293T cells resulted in Nmi-induced activation of type I IFN promoters which was found to be dependent on the expression of IFP35 (Zheng et al., 2014) since its depletion obliterated the response.