IRF7 and viral infectious disease: It is known that IRF7, is the master regulator of IFNα expression and strong upregulation is detected upon viral infection (Honda et al., 2005); however, no consistency in the expression of IRF7 could be detected in bovine tissues isolated from FMDV infected cattle, with up- or down- temporal regulation depending on the study (Stenfeldt et al., 2018).