IFNA1 and viral infectious disease: In fact, it has been demonstrated that when IFN (either type I, type II, or type III IFNs) -mediated antiviral stage is induced prior to virus infection, replication of all seven FMDV serotypes can be dramatically inhibited (Chinsangaram et al., 1999, 2001; Moraes et al., 2007; Díaz-San Segundo et al., 2011; Grubman et al., 2012).