Previous studies have reported that MT is an exclusive pathogenic characteristics in IBD/IBS (Abdul et al., 2016), graft-versus-host disease (Eriguchi et al., 2012) and HIV disease (Yim et al., 2009), which feature increased levels of LPS-sCD14 and EndoCAb-IgM. The gene discussed is CD40LG; the disease is graft versus host disease.