A case study of an infant with congenital combined pituitary hormone deficiency (CCPHD) presenting cholestasis, focused on the histology of liver after hormone replacement therapy with growth hormone, thyroid hormone and hydrocortisone (68), and concluded that pituitary-mediated hormones, especially cortisol may be essential for the normal development of the bile ducts in neonates. The gene discussed is TG; the disease is cholestasis.