After adjusting for age, sex, years of education, APOE-ε4 genotype, BMI, depression, diabetes, hypertension and stroke, the non-matched models indicated that the OR of high LDL-C level (OR [95%CI] = 0.56[0.30, 1.04]) had an upper limit awfully close to the null threshold. The gene discussed is APOE; the disease is depressive symptom measurement.