A third study demonstrated CMHs and bilateral increased extravasation of the plasma protein immunoglobulin G (IgG) with co-localized matrix metalloproteinase-9 (MMP-9) immunoreactivity in the external capsule, corpus callosum, and internal capsule in SP-SHR with unilateral carotid artery occlusion and on a stroke-permissive diet (Japanese-style) (n = 5) compared with sham-operated SP-SHR on a regular diet (n = 5) (28). The gene discussed is MMP9; the disease is stroke disorder.