KL and diabetes mellitus: Thus, the reduced plasma levels of Klotho might contribute to the cardiovascular and renal abnormalities observed in ZO rats, since reduced circulating Klotho also have been reported in other renal (Hu et al., 2010b, 2011, 2012; Akimoto et al., 2012; Scholze et al., 2014) or CVDs (Wang and Sun, 2009; Yu et al., 2010), including diabetes in humans and mice (Zhao et al., 2011; Asai et al., 2012).