Lactobacillaceae fermentation has been shown to produce powerful bioactive peptides with the capability to inhibit ACE (Fuglsang et al., 2003; Barla et al., 2016), a key enzyme of the renin-angiotensin system (RAS) positively correlated with HTN (Wang et al., 2011; He et al., 2013). The gene discussed is REN; the disease is hypertensive disorder.