MYC and colorectal carcinoma: It was reported that overexpression of either c-Myc mRNA or c-Myc protein in CRC patients was associated with favorable survival (Smith and Goh, 1996; Toon et al., 2014), but these were opposite results to previous studies that showed that high expression of c-Myc in CRC predicted worse survival outcome (Erisman et al., 1988).