Apoptosis, though stably eliminating tumor cells, thus fulfilling the primary goal of anticancer therapies, may nonetheless act as Trojan horse, since caspase-3, the main executioner of the intrinsic and extrinsic apoptotic pathways (Coppola and Ghibelli, 2000), is emerging as a major actor of tumor tissue reconstitution after cytotoxic therapy (Huang et al., 2011; Shalini et al., 2014). Here, CASP3 is linked to neoplasm.