CASP3 and cancer: Clinically, high caspase-3 levels are a bad prognostic factor in cancer patients (Amptoulach et al., 2015), and caspase inhibition has been proposed as adjuvant to prevent repopulation (Flanagan et al., 2016): all this suggests that aiming at inducing caspase-3-independent apoptosis would be a sensible goal of anticancer therapies.