However, high doses of mGlu5 antagonist are also effective at reducing binge-alcohol drinking (Cozzoli et al., 2012), as well as the positive reinforcing properties of alcohol (Gass and Olive, 2009; Besheer et al., 2010; Sinclair et al., 2012) when infused intra-AcbSh and thus, our present immunohistochemical results may have relevance for understanding how mGlu5 inhibitors exert their “anti-alcoholism” effects. This evidence concerns the gene GRM5 and alcohol dependence.