The fact that both systemic treatment with, and intra-AcbSh infusion of, low MTEP doses are more effective than higher MTEP doses at reducing withdrawal-induced hyper-anxiety in adult-onset drinkers, in the absence of any overt motor side-effects or effects upon emotionality expressed by alcohol-naïve animals (Figures 3, 4; Lee et al., 2017a,b), argues the relative safety of mGlu5 antagonists. Here, GRM5 is linked to Anxiety.