GRM5 and Anxiety: Given that: (1) mGlu5 expression is up-regulated during withdrawal from binge-drinking (Cozzoli et al., 2012; Lee et al., 2016); (2) inhibiting AcbSh activity produces an anxiolytic effect (Lopes et al., 2012) and (3) mGlu5 inhibition within the AcbSh reduces signs of opioid withdrawal-induced anxiety (Radke and Gewirtz, 2012; Lou et al., 2014), the present study tested for a cause-effect relation between the coincident increase in AcbSh mGlu5 expression and hyper-emotionality during binge-alcohol withdrawal (Lee et al., 2016, 2017c).