IL2 and neoplasm: Nevertheless, despite TNF-α, INF-γ, and IL-2 possessing anti-tumor potency, the systemic clinical applications of high doses of these drugs are severely limited due to their systemic toxicities, for instance, inflammatory response, and underlying cardiotoxicity (Ashkenazi et al., 1999; Berek, 2000; Liang et al., 2012).