But like in our case the diagnosis of LC can be challenging: Immuno-histochemistry can be very helpful in the process with MPO resembling a strong marker for myeloid cells while CD34 or CD117 remain very often negative (Traweek et al., 1993; Cronin et al., 2009; Li et al., 2018). This evidence concerns the gene CD34 and laryngotracheoesophageal cleft.