Biomarkers involved in inflammation (high-sensitivity C-reactive protein, interleukin-6), endothelial dysfunction (plasminogen activator inhibitor, soluble intercellular adhesion molecule), myocardial ischemia (fatty acid binding protein, glycogen phosphorylase BB) and NRG-1 have been also considered as diagnostic markers of cardiotoxicity (Curigliano et al., 2016). The gene discussed is NRG1; the disease is endothelial dysfunction.