The functional relevance of TRPM8 upregulation in prostatic cancer cells as a target for suppressing their proliferation was documented by showing that inhibition of TRPM8 upregulation with highly specific blockers, AMTB, JNJ41876666, and RNAi suppressed increased proliferation rates in all tumor cells but not in non-tumor prostate cells (Valero et al., 2012). Here, TRPM8 is linked to Familial prostate cancer.