Even though menthol activates TRPM8 (Eccles, 1994; Galeotti et al., 2002; Bautista et al., 2007; Pedretti et al., 2009), the magnitudes of these transients did not correlate with the TRPM8 expression levels in certain cancer cells indicating a TRPM8-independent signaling pathway (Naziroglu et al., 2018). This evidence concerns the gene TRPM8 and cancer.