In CA1 SR of 6 months old transgenic mice, we found significantly higher levels of the expression of the cytokines TNF-α, IL1β, as well as iNOS in astrocytes, confirming our and others’ results in TgCNRD8 mice (Luccarini et al., 2012) and other models of neurodegenerative diseases (Deng et al., 2014; Lana et al., 2017). Here, TNF is linked to neurodegenerative disease.