SLIT3 and Anxiety: Moreover, it was reported that, depending on the types of behavioral tests used, mouse strain and gender have different impacts on anxiety measures (Griebel et al., 2000; Võikar et al., 2001; An et al., 2011), which may explain the results that male Slit3-KO mice exhibited increased anxiety-like behaviors only in the light/dark box test but not in the other two tests.