Our group has characterized such activation identifying a broad panel of proteins (cellular adhesion molecules, CAMs; e.g., LFA-1, ALCAM, and E-selectin) that are highly upregulated in tumor-associated microglia together with other brain cell types (e.g., endothelial cells and astrocytes) within the TME (Soto et al., 2014). This evidence concerns the gene ALCAM and neoplasm.