LRRK2 and Parkinson disease: Importantly, our data further suggest that centrosomal cohesion deficits may comprise a valid cellular biomarker readout for testing the efficacy of LRRK2 kinase inhibitors in clinical trials, as centrosomal cohesion deficits are also observed in distinct peripheral cell types derived from G2019S LRRK2-PD patients as compared to healthy controls (Madero-Perez et al., 2018).