LRRK2 and Parkinson disease: Our findings suggest that RAB7L1 regulates LRRK2 Golgi localization with downstream effects on centrosomal behavior in a manner dependent on LRRK2-mediated RAB8A phosphorylation, and indicate that the centrosomal cohesion phenotype may comprise a cellular biomarker in peripheral patient-derived cells for a broader spectrum of PD.