RYR2 and catecholaminergic polymorphic ventricular tachycardia: Generally, CPVT is an SR Ca2+ handling disease, most often caused by RyR2 mutations, whereas LQTS involves dysregulation of ion-fluxes across the sarcolemma, e.g., Ca2+ flux disturbances caused by mutations in CaV1.2 (Landstrom et al., 2017).