The major findings of the present study were as follows: (1) Rats with 4 weeks of chronic ischemia displayed a significant synaptic loss and cognitive deficits; (2) miR-210-5p was increased significantly in the hippocampus of VD model rats and Snap25 mRNA is targeted by miR-210-5p; and (3) miR-210-5p agomir aggregates cognitive impairment of VD model and leads to more synaptic loss, and miR-210-5p agomir downregulated Snap25 mRNA level and protein expression in vivo. The gene discussed is SNAP25; the disease is sexually transmitted disease.