The associations remain significant after accounting for Aβ1–42 and T‐tau (Model 3) for ADNI‐EF, ADAS‐Cog 11 and ADAS‐Cog 13, and a tendency existed for ADNI‐Mem and MMSE (Table 5, Appendix Table S6), indicating that the association between CSF PGRN and cognitive scores is, at least in part, not dependent on the AD CSF core biomarkers. Here, MAPT is linked to Alzheimer disease.