Conversely, treatment with an anti-PD-L1 antibody leads to a significant increase in IFN-γ secretion by CLL T lymphocytes [44], and coincubation of CD4+ or CD8+ T cells with sPD-L1-producing cells and mDC-derived sPD-L1 induces T cells to undergo apoptosis [31]. This evidence concerns the gene IFNG and B-cell chronic lymphocytic leukemia.