Because of the need for the endogenous molecule used for therapy, the formation mechanisms and functions of soluble receptors and ligands produced by human body, such as sPD-1, are being explored [17].Due to the rapid development of Immune checkpoint therapy, it will likely become the most effective way to fight cancer, although this therapy still has some limitations, such as a lack of power in the TME [18]. Here, HOXD13 is linked to cancer.