Similar to the study above, studies by both Wang and Huang’s teams found that the overall response rate to treatment was higher in low sPD-L1 patients than in high sPD-L1 patients with MM (multiple myeloma), indicating a poorer prognosis in patients with higher levels of sPD-L1 (> 2.783 ng/mL) [39, 40]. The gene discussed is SPDL1; the disease is plasma cell myeloma.