In their study of PTEN mutation spectrum and genotype-phenotype correlations in BRRS and Cowden’s syndrome, Marsh et al. showed the overlap of a number of clinical features, the sharing of identical PTEN mutations, in addition to the presence of BRRS/Cowden’s syndrome overlap families, all highly suggestive that BRRS and Cowden’s syndrome are different presentations of a single syndrome and that anticipation may also pertain in this syndrome [22]. The gene discussed is PTEN; the disease is Cowden disease.