For example, SOX2OT is up-regulated in glioma tissue and glioblastoma stem cells, and knockdown of SOX2OT inhibits the proliferation, migration and invasion of cells, and the SOX2OT-miR-194-5p/miR-122-SOX3-TDGF-1 pathway forms a positive feedback loop for glioma cell stemness [26]. The gene discussed is SOX3; the disease is central nervous system cancer.