To further assess the anti-tumor effect of USP37 downregulation on tumor growth and cisplatin sensitivity in vivo, we established a xenograft tumor models by subcutaneously injecting breast cancer MCF-7 cells, which had been transfected with USP37#2 shRNA or scramble shRNA, into the mammary gland of nude mice (Fig. 8a). The gene discussed is USP37; the disease is breast carcinoma.