Indeed, Pgp-positive cancer cells: i) do not accumulate the intracellular amount of doxorubicin sufficient to increase NO production [16] and induce ICD [17]; ii) do not induce C/EBP-β LIP and ER stress-dependent cell death [5], a condition necessary for the translocation of CRT on cell surface and the subsequent ICD [3]; iii) are not phagocytized by DC since Pgp hampers the immune-activating functions of CRT in plasma-membrane [20]. This evidence concerns the gene CALR and cancer.