The pathogenesis of HIV/HHV-8 coinfection is complex and can be influenced by viral factors; for example, HIV induces the HHV-8 lytic cycle through the activation of the RTA protein and the TAT protein, and HHV-8 interferes with HIV replication by regulating the LTR by LANA antigen [36–40]. The gene discussed is TAT; the disease is coinfection.