Multiple pathways underlying cachexia have been identified through murine models, including signaling pathways via tumor necrosis factor receptor superfamily member 12A, role of parathyroid hormone in influencing metabolic states or energy wasting through white adipose tissue through inactivation of 5′ adenosine monophosphate-activated protein kinase [48]. This evidence concerns the gene TNFRSF12A and Cachexia.