Multivariable forward stepwise linear regression analysis revealed that age (β = 0.325, adjusted R2 change = 0.109, p < 0.001), SBP (β = 0.236, adjusted R2 change = 0.061, p = 0.004), iPTH (β = 0.185, adjusted R2 change = 0.032, p = 0.022), HDL-C (β = − 0.193, adjusted R2 change = 0.025, p = 0.027), and sclerostin levels (β = 0.255, adjusted R2 change = 0.146, p = 0.003) were independent predictors of cfPWV values in our patients with hypertension. The gene discussed is SOST; the disease is hypertensive disorder.