These ontologies encompass such immune system processes as antigen binding, T- and B-cell activation, signaling pathways, cytokine production, chemokine activity, and inflammatory responses, all of which appear to play a role in Sjögren syndrome pathogenesis.4,58,59 The increased expression of KEGG pathways related to lysosomes and Fcγ R-mediated phagocytosis was of particular interest, because they have been reported as the only pathways common to the development of the four autoimmune diseases type 1 diabetes mellitus, SLE, multiple sclerosis, and rheumatoid arthritis.60 This evidence concerns the gene FCGR2A and Sjogren syndrome.