Examples of such conformational diseases include cystic fibrosis resulting from cystic fibrosis transmembrane conductance regulator (CFTR) misfolding [8], type 2 long QT syndrome resulting from trafficking deficiency of human ether-à-go-go-related gene (hERG) channels [9,10], congenital myasthenic syndromes resulting from misfolding of nicotinic acetylcholine receptors [11], and idiopathic epilepsy resulting from misfolding of γ-aminobutyric acid type A (GABAA) receptors [12,13]. This evidence concerns the gene CFTR and cystic fibrosis.