HDAC1 and Hepatic fibrosis: Pirfenidone, but also LBH589, reduced significantly the protein expression of HDAC1 (Fig 5A), HDAC2 (Fig 5B), and of a ~66 kDa isoform of class-IIa-HDAC9 (Fig 5D), a HDAC comprising several alternatively spliced isoforms with profibrotic function in liver fibrosis [50].