HDAC6 and pulmonary fibrosis: Moreover, tubastatin also ameliorated bleomycin-induced lung fibrosis in mice in vivo, whereas Hdac6(-/-) knockout mice where not protected against collagen production and lung fibrosis induced by bleomycin, as compared to wild-type mice, despite pronounced hyperacetylation of α-tubulin in isolated lung fibroblasts of Hdac6 deficient mice.