We found significantly lower VDR mRNA expression in tuberculoid and lepromatous group of leprosy while we noted no significant difference in the level of vitamin D. Low level of gene expression VDR gene in leprosy patients in comparison to HCs might be associated with the VDR gene polymorphism found in leprosy patients and one study Selvaraj et al (2009) have reported that vitamin D has no effect on the mRNA expression of VDR in tuberculosis patients [40]. The gene discussed is VDR; the disease is leprosy.