Since, osteoporosis is a major problem in lepromatous forms of leprosy along with conflicting reports on vitamin D levels in leprosy, the present study has been undertaken to find out the associations of vitamin D level and mRNA VDR gene expression VDR gene in leprosy patients and in reaction (T1R and T2R) group of leprosy. The gene discussed is VDR; the disease is leprosy.