Multivariate analysis showed that high mRNA expressions of CBX1 (HR= 1.534, 95% CI: 1.167-2.018, and p=0.002), CBX2 (HR= 1.349, 95% CI: 1.198-1.519, and p<0.001), CBX3 (HR= 1.691, 95% CI: 1.175-2.432, and p=0.005), CBX6 (HR= 1.124, 95% CI: 1.001-1.261, and p=0.048), CBX8 (HR= 1.300, 95% CI: 1.036-1.631, and p=0.023) were independently associated with significantly shorter OS of liver cancer patients (Supplementary Tables 3-10). The gene discussed is CBX3; the disease is liver cancer.