In Roessler Liver 2 dataset, CBX1 over-expression was found in HCC tissues compared with normal tissues with a fold change of 2.688 (p=4.33E-80) [16], while Wurmbach observed 1.781-fold increase in CBX1 mRNA expression in HCC samples (p=4.38E-8) [17] and Roessler found 2.405-fold increase in CBX1 mRNA expression in HCC tissues (p=1.37E-7) [16]. Here, CBX1 is linked to hepatocellular carcinoma.