On one hand, decreased expression of CBX7 had been found in most of the human malignant carcinomas, including bladder cancers, thyroid cancers, colorectal cancers, breast cancers and lung carcinomas, and in these cancers, down-regulation of CBX7 had been shown to correlate with cancer aggressiveness and poor prognosis, suggesting an oncosuppressor role of CBX7 in these cancers [36–40]. The gene discussed is CBX7; the disease is cancer.